Project's holder : Association Neurogel en Marche (France) chaired by Pierre Rondio , and it's scientific council

Partner of the therapeutical project : University of Milan (Italy) Pr Alfredo Gorio (Chief scientist of Italian national program on spinal chord injury)

Partner of the clinical project : International Center forTreatment of Spinal Chord Injury , Kunming (China) 

Chief Neurosurgeon : Pr Liu Yansheng

Partner of functional rehabilitation project : International Center forTreatment of Spinal Chord Injury , Kunming (China) Pr Zhu Hui (Director of rehabilitation center of Kunming)

Project's holder : Association Neurogel en Marche (France) chaired by Pierre Rondio , and it's scientific council

Partner of the therapeutical project : University of Milan (Italy) Pr Alfredo Gorio (Chief scientist of Italian national program on spinal chord injury)

Partner of the clinical project : International Center forTreatment of Spinal Chord Injury , Kunming (China)

Chief Neurosurgeon : Pr Liu Yansheng

Partner of functional rehabilitation project : International Center forTreatment of Spinal Chord Injury , Kunming (China) Pr Zhu Hui (Director of rehabilitation center of Kunming)

In March 2019, 12 patients (9 paraplegics 3 quadriplegics) have been operated with actived fat in their spinal chord injury. Surgery and one year rehabilitation took place at the International Center forTreatment of Spinal Chord Injury , Kunming by Pr Liu Yansheng and Pr Zhu Hui. All lesion were severe. Patients were aged from 20 to 55 years old, spinal injuries aged from 1 to 23 years, 3 patients with 10+ years old injuries. The cost per patients was 80 000€, financed by the donations to the association according to Helsinki Convention. French patients are now back to their family after a one year intensive rehabilitation program.

In March 2019, 12 patients (9 paraplegics 3 quadriplegics) have been operated with actived fat in their spinal chord injury. Surgery and one year rehabilitation took place at the International Center forTreatment of Spinal Chord Injury , Kunming by Pr Liu Yansheng and Pr Zhu Hui. All lesion were severe. Patients were aged from 20 to 55 years old, spinal injuries aged from 1 to 23 years, 3 patients with 10+ years old injuries. The cost per patients was 80 000€, financed by the donations to the association according to Helsinki ConventionFrench patients are now back to their family after a one year intensive rehabilitation program.

The team of Pr HUI and YANSHENG is regularly using the protocol that established the regretted Pr Antonio REIS for the implantation of actived fat. They have realised more than 5000 operations on both chronic and acute injuries using differents protocols. Surgery is a crucial point to free spinal chord from constraints linked to diverses pressions.

The team of Pr HUI and YANSHENG is regularly using the protocol that established the regretted Pr Antonio REIS for the implantation of actived fat. They have realised more than 5000 operations on both chronic and acute injuries using differents protocols. Surgery is a crucial point to free spinal chord from constraints linked to diverses pressions.

The hospital have an intensive functional rehabilitation center. Physiotherapy is an essential point and have to last at least twelve month. Implantation of actived fat without rehabiltation do not allow growth of nervous fibers into synapse. The 36 hours/week intensive rehabilitation program of Pr Zhu Hui is mainly focused on walking and active exercises (with the least technical help) , walking is the main focusIt is important for patients to support the maximum of their weight while walking so that the sensitive return is the closest to reality. The whole protocol is composed of walking, mobilisations, acupuncture, static stand-up, floor exercises, low frequency electrosimulation and physiotherapy. Progress are evaluated with the program created by Pr HUI, the Kunming Scale. Patient are housed in the center and benefit from all necessary nursing.

The hospital have an intensive functional rehabilitation center. Physiotherapy is an essential point and have to last at least twelve month. Implantation of actived fat without rehabiltation do not allow growth of nervous fibers into synapse. The 36 hours/week intensive rehabilitation program of Pr Zhu Hui is mainly focused on walking and active exercises (with the least technical help) , walking is the main focusIt is important for patients to support the maximum of their weight while walking so that the sensitive return is the closest to reality. The whole protocol is composed of walking, mobilisations, acupuncture, static stand-up, floor exercises, low frequency electrosimulation and physiotherapy. Progress are evaluated with the program created by Pr HUI, the Kunming Scale. Patient are housed in the center and benefit from all necessary nursing.

Results have been beyond our expectations and can be considered has a world premiere

  • First clinical trial on humans, drived and financed by an association of patients.

  • First succesfull graft of autologous adipose tissue in the central nervous system, associated with EPO without reject or side effect. Confirmed clinical process safe for the patient.

  • First functional and sphincteral recovery for patients having an old complete lesion (ASIA-A).

  • All patients are able to walk with a high walker with or without technical aid, even quadriplegics, one using only ropes (Kunming Scale).

  • They are all able, at different degrees, to launch their legs and control the alternate movement of walking.

  • About Paraplegic patients have improved the most. Five are able to move alone with an high walker without technical help and to stand without supports. Two of them are able to walk alone with crutches. One of them is able to stand up from his wheelchair alone with crutches and to mount stairs.

  • Most of the patients had variable genital and sphincteral improvementsfeeling of need to pee or defecate. an improved vesical capacity without leakage; the capacity to control urinary or fecal function, an improved sensibility in sacred area. Most of them no longer have a neurological bladder and/or have develloped profound sensitivity.

  • The sensitive recovery is longer but tingling, profound sensations, electric shocks, hot and cold sensations begin to appear for multiple patients.

Results have been beyond our expectations and can be considered has a world premiere

  • Première fois qu’une association de personnes paralysées a mené et organisé une étude clinique.
  • Première greffe réussie de tissu adipeux autologue associée à l’EPO et activée mécaniquement dans le système nerveux central sans rejet et sans effets secondaires. Solution clinique sûre et réalisable sans risques pour le patient.
  • Premières récupérations fonctionnelles et sphinctériennes pour des blessés avec une lésion ancienne complète (ASIA-A).
  • Tous les patients ont fini par marcher au déambulateur haut avec ou sans aide technique, même les patients tétraplégiques dont un, capable de marcher avec des cordes.
  • Les patients arrivent plus ou moins à lancer leurs jambes et à dissocier le mouvement.
  • Les résultats les plus spectaculaires concernent 5 patients paraplégiques capables de se déplacer seuls en déambulateur haut sans aucune aide technique et de tenir debout sans support entre des barres parallèles. 2 de ces patients sont capables de marcher seul avec des béquilles, ce qui est très impressionnant. Un d’entre eux est capable de monter des marches et arrive à se lever seul de son fauteuil avec ses béquilles.
  • La plupart des patients ont eu des améliorations génito-sphinctériennes variables allant de la sensation du besoin d’uriner, de déféquer, une capacité vésicale augmentée sans fuites, la capacité de commander la fonction urinaire ou fécale, une sensibilité plus forte dans la zone sacrée. La plupart n’ont plus de vessie neurologique et/ou ont développé des sensations profondes.
  • La récupération sensitive est plus longue mais des fourmillements, des sensations profondes, des décharges électriques, des sensations au chaud ou au froid commencent à apparaître.

Our study is a major step in the desert of spinal chord injury research.
Scientifically it shows that epigenetic is has much promising then genetic and genetic manipulation with a certain security and better visibilty on ethical issues. Changing the environnement of a tissue give him an different physiological expression without touching DNA of the cells that compose him, this modification is lasting. Actived fat developed by Milan's University and stem cells that derive from it open important therapeutical perspectives. We know that actived fat showed great results for treatment of bedsores but surely for Parkinson desease, brain cancer, scleroderma, burns and other dermal issue too.

Our study is a major step in the desert of spinal chord injury research.
Scientifically it shows that epigenetic is has much promising then genetic and genetic manipulation with a certain security and better visibilty on ethical issues. of bedsores but surely for Parkinson desease, brain cancer, scleroderma, burns and other dermal issue too.

assoneurogel@gmail.com